The use of oxytocin to improve feeding and social skills in infants with Prader–Willi syndrome

M Tauber, K Boulanouar, G Diene… - …, 2017 - publications.aap.org
METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of
intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 …

Oxytocin treatment in children with Prader–Willi syndrome: A double‐blind, placebo‐controlled, crossover study

JL Miller, R Tamura, MG Butler… - American journal of …, 2017 - Wiley Online Library
Prader–Willi syndrome (PWS) is a rare, complex multisystem genetic disorder which
includes hypothalamic dysfunction, hyperphagia, cognitive and behavioral problems …

Promising effects of oxytocin on social and food‐related behaviour in young children with Prader–Willi syndrome: a randomized, double‐blind, controlled crossover …

RJ Kuppens, SH Donze… - Clinical …, 2016 - Wiley Online Library
Summary Background Prader–Willi syndrome (PWS) is known for hyperphagia with
impaired satiety and a specific behavioural phenotype with stubbornness, temper tantrums …

Oxytocin in young children with Prader‐Willi syndrome: Results of a randomized, double‐blind, placebo‐controlled, crossover trial investigating 3 months of oxytocin

L Damen, LN Grootjen, AF Juriaans… - Clinical …, 2021 - Wiley Online Library
Abstract Context Prader‐Willi syndrome (PWS) is characterized by hypothalamic
dysfunction, hyperphagia and a typical behavioural phenotype, with characteristics of autism …

Intranasal oxytocin versus placebo for hyperphagia and repetitive behaviors in children with Prader-Willi Syndrome: A randomized controlled pilot trial

E Hollander, KG Levine, CJ Ferretti, K Freeman… - Journal of Psychiatric …, 2021 - Elsevier
Objective The effects of intranasal oxytocin and placebo on hyperphagia and repetitive
behaviors were compared in children and adolescents with Prader Willi Syndrome (PWS) …

Elevated plasma oxytocin levels in children with Prader–Willi syndrome compared with healthy unrelated siblings

L Johnson, AM Manzardo, JL Miller… - American Journal of …, 2016 - Wiley Online Library
Prader–Willi syndrome (PWS) is a rare genetic disorder associated with distinct abnormal
behaviors including hyperphagia, profound social deficits, and obsessive‐compulsive …

A double‐blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome

SL Einfeld, E Smith, IS McGregor… - American journal of …, 2014 - Wiley Online Library
Individuals with Prader–Willi syndrome (PWS) have a significant reduction in the number of
oxytocin‐producing neurons (42%) in the hypothalamic paraventricular nucleus. A number …

Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in …

M Tauber, C Mantoulan, P Copet, J Jauregui… - Orphanet Journal of …, 2011 - Springer
Abstract Background Prader-Willi syndrome (PWS) is a complex neurodevelopmental
genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and …

Mental and motor development before and during growth hormone treatment in infants and toddlers with Prader–Willi syndrome

DAM Festen, M Wevers, AC Lindgren… - Clinical …, 2008 - Wiley Online Library
Summary Background Prader–Willi syndrome (PWS) is a neurogenetic disorder
characterized by muscular hypotonia, psychomotor delay, feeding difficulties and failure to …

Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome

AP Goldstone, AJ Holland, JV Butler… - International journal of …, 2012 - nature.com
Objective: Prader–Willi syndrome (PWS) is a genetic neurodevelopmental disorder with
several nutritional phases during childhood proceeding from poor feeding, through normal …