Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

L Zhang, X Cheng, Y Gao, J Zheng, Q Xu, Y Sun… - Food & function, 2015 - pubs.rsc.org
Apigenin, abundantly present in fruits and vegetables, is recognized as a flavonoid with anti-
inflammatory, antioxidant and anticancer properties. In this study, we first investigated the …

[HTML][HTML] Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

J Yang, C Pi, G Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Apigenin is a dietary flavonoid with known antioxidant and antitumor effects against several
types of cancers by promoting cell death and inducing cell cycle arrest. Apigenin also …

Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

Y Lee, B Sung, YJ Kang, DH Kim… - International …, 2014 - spandidos-publications.com
Abstract Apigenin (4', 5, 7-trihydroxyflavone) is a natural flavonoid, shown to have
chemopreventive and/or anticancer properties in a variety of human cancer cells. The …

[HTML][HTML] Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells

X Cao, B Liu, W Cao, W Zhang, F Zhang… - Chinese Journal of …, 2013 - ncbi.nlm.nih.gov
Abstract Apigenin (4', 5, 7-trihydroxyflavone) is a member of the flavone subclass of
flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin …

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

MD Shi, CK Shiao, YC Lee, YW Shih - Cancer cell international, 2015 - Springer
Background Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and
therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However …

A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells

BR Kim, YK Jeon, MJ Nam - Food and chemical toxicology, 2011 - Elsevier
Apigenin (APG) has been shown to have a strong anti-cancer effect on various cancer
models via a programmed cell death, apoptosis. However, the fundamental mechanisms of …

[HTML][HTML] Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo

Y Liang, Q Zhong, R Ma, Z Ni, K Thakur, J Zhang… - Food Science and …, 2023 - Elsevier
Apigenin, a natural flavonoid has been reported against a variety of cancer types. However,
it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells …

Punicalagin induces apoptosis-independent autophagic cell death in human papillary thyroid carcinoma BCPAP cells

X Cheng, Y Gao, X Yao, H Yu, J Bao, H Guan, Y Sun… - RSC …, 2016 - pubs.rsc.org
Thyroid cancer is the most common endocrine carcinoma with increased incidence
worldwide. Punicalagin is a tannin in pomegranate and contributes to a variety of …

Reduction of apoptosis by proanthocyanidin-induced autophagy in the human gastric cancer cell line MGC-803

C Nie, J Zhou, X Qin, X Shi, Q Zeng… - Oncology …, 2016 - spandidos-publications.com
Proanthocyanidins are flavonoids that are widely present in the skin and seeds of various
plants, with the highest content in grape seeds. Many experiments have shown that …

Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

JMM Salmani, XP Zhang, JA Jacob… - Chinese journal of natural …, 2017 - Elsevier
Cancer is a major health concern and leading burden on economy worldwide. An increasing
effort is devoted to isolation and development of plant-derived dietary components as …