Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …

Abstract Solute carrier family 26, member 3 (Slc26a3), also termed downregulated-in-
adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in …

Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …

Inorganic sulfate (SO42−) is essential for a multitude of physiological processes. The
specific molecular pathway has been identified for uptake from the small intestine but is …

Slc26a9 is an anion transporter that is strongly expressed in the stomach and lung. Slc26a9
variants were recently found associated with a higher incidence of meconium ileus in cystic …

Abstract Aim SLC26A3 (DRA) mediates the absorption of luminal Cl− in exchange for
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …

Mutations in the human SLC26A3 gene, also known as down‐regulated in adenoma
(hDRA), cause autosomal recessive congenital chloride‐losing diarrhoea (CLD). hDRA …

BACKGROUND & AIMS: Electroneutral NaCl absorption across small intestine contributes
importantly to systemic fluid balance. Disturbances in this process occur in both obstructive …

The ileum is considered the primary site of inorganic sulfate (SO 4 2−) absorption. In the
present study, we explored the contributions of the apical chloride/bicarbonate (Cl−/HCO 3−) …

Congenital chloride diarrhea (CLD) is an autosomal recessive disorder of intestinal
electrolyte absorption. It is characterized by persistent secretory diarrhea resulting in …