Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …

The intimate connection between telomerase regulation and human disease is now well
established. The molecular basis for telomerase regulation is highly complex and entails …

Telomerase has been recognized as a relevant factor distinguishing cancer cells from
normal cells. Thus, it has become a very promising target for anticancer therapy. The cell …

Telomerase synthesizes telomeres at the ends of human chromosomes during S phase. The
results presented here suggest that telomerase activity may be regulated by intranuclear …

The identities and roles of proteins associated with human telomerase remain poorly
defined. To gain insight, we undertook an affinity purification of endogenously assembled …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …

Telomerase is a specialized reverse transcriptase conserved throughout almost all
eukaryotic life. It plays a fundamental role in genome maintenance, adding back the …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …