Platinum (Pt)-based chemotherapy drugs such as cisplatin are the first line and core options
for the treatment of ovarian cancer (OC), while cisplatin resistance has a worse prognosis …

Given that currently used classical chemotherapeutic drugs lack the ideal therapeutic effect
and produce severe side effects, platinum nanomaterials (Pt-NMs) have gradually gained …

Failure to engage apoptosis appears to be a leading mechanism of resistance to traditional
platinum drugs in patients with ovarian cancer. Therefore, an alternative strategy to induce …

Background The enhancement of platinum-based chemotherapeutic agents utilizing
nanotechnology holds promise for improving the prognosis of osteosarcoma chemotherapy …

Platinum resistance represents a huge difficulty in ovarian cancer treatment, resulting in
disease recurrence and deaths in patients. However, platinum-resistant, recurrent diseases …

Drug resistance to the conventional platinum chemotherapy remains a major challenge for
treating ovarian cancer. Herein, we present a novel approach to overcome the drug …

In recent years, multifunctional platinum nanoclusters (Pt-NCs) as new Pt-based anti-cancer
drugs exhibit a promising therapeutic efficiency for several cancer diseases, especially for …

In photodynamic therapy (PDT), elevated reactive oxygen species (ROS) activate tumor cell
protective autophagy, therefore attenuating the antitumor function of therapy. Hence …

Background Platinum resistance is a major challenge in the management of ovarian cancer.
Even low levels of acquired resistance at the cellular level lead to impaired response to …

Agents with multiple modes of tumor cell death can be effective chemotherapeutic drugs.
One example of a bimodal chemotherapeutic approach is an agent that can induce both …