From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

O Massidda, L Nováková… - Environmental …, 2013 - Wiley Online Library
S treptococcus pneumoniae is an oval‐shaped G ram‐positive coccus that lives in intimate
association with its human host, both as a commensal and pathogen. The seriousness of …

[HTML][HTML] The Pneumococcal Divisome: Dynamic Control of Streptococcus pneumoniae Cell Division

NS Briggs, KE Bruce, S Naskar, ME Winkler… - Frontiers in …, 2021 - frontiersin.org
Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by
a protein complex consisting of at least 14 different protein elements; known as the …

[HTML][HTML] Nanoscale dynamics of peptidoglycan assembly during the cell cycle of Streptococcus pneumoniae

J Trouve, A Zapun, C Arthaud, C Durmort, AM Di Guilmi… - Current Biology, 2021 - cell.com
Dynamics of cell elongation and septation are key determinants of bacterial morphogenesis.
These processes are intimately linked to peptidoglycan synthesis performed by …

Roles of the essential protein FtsA in cell growth and division in Streptococcus pneumoniae

A Mura, D Fadda, AJ Perez, ML Danforth… - Journal of …, 2017 - Am Soc Microbiol
Streptococcus pneumoniae is an ovoid-shaped Gram-positive bacterium that grows by
carrying out peripheral and septal peptidoglycan (PG) synthesis, analogous to model bacilli …

Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of Streptococcus pneumoniae

AJ Perez, MM Lamanna, KE Bruce… - Proceedings of the …, 2024 - National Acad Sciences
Ovoid-shaped bacteria, such as Streptococcus pneumoniae (pneumococcus), have two
spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the …

Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39

AD Land, HCT Tsui, O Kocaoglu, SA Vella… - Molecular …, 2013 - Wiley Online Library
Bacterial cell shapes are manifestations of programs carried out by multi‐protein machines
that synthesize and remodel the resilient peptidoglycan (PG) mesh and other polymers …

CozE is a member of the MreCD complex that directs cell elongation in Streptococcus pneumoniae

AK Fenton, L El Mortaji, DTC Lau, DZ Rudner… - Nature …, 2016 - nature.com
Most bacterial cells are surrounded by a peptidoglycan cell wall that is essential for their
integrity. The major synthases of this exoskeleton are called penicillin-binding proteins …

Organization of peptidoglycan synthesis in nodes and separate rings at different stages of cell division of Streptococcus pneumoniae

AJ Perez, MJ Boersma, KE Bruce… - Molecular …, 2021 - Wiley Online Library
Bacterial peptidoglycan (PG) synthesis requires strict spatiotemporal organization to
reproduce specific cell shapes. In ovoid‐shaped Streptococcus pneumoniae (Spn), septal …

LocZ is a new cell division protein involved in proper septum placement in Streptococcus pneumoniae

N Holečková, L Doubravová, O Massidda, V Molle… - MBio, 2015 - Am Soc Microbiol
How bacteria control proper septum placement at midcell, to guarantee the generation of
identical daughter cells, is still largely unknown. Although different systems involved in the …

The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a

AD Land, ME Winkler - Journal of bacteriology, 2011 - Am Soc Microbiol
MreC and MreD, along with the actin homologue MreB, are required to maintain the shape
of rod-shaped bacteria. The depletion of MreCD in rod-shaped bacteria leads to the …