The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Tumors are highly heterogeneous tissues where malignant cells are surrounded by and
interact with a complex tumor microenvironment (TME), notably composed of a wide variety …

The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …

Recent advances in cancer immunology have led to a better understanding of the role of the
tumor microenvironment (TME) in tumor initiation, progression, and metastasis. Tumors can …

Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

Cancers display significant heterogeneity with respect to tissue of origin, driver mutations,
and other features of the surrounding tissue. It is likely that individual tumors engage …

We performed a comprehensive immuno-genomic analysis of tumor microenvironment
immune types (TMITs), which is classified into four groups based on PD-L1+ CD8A or PD …

The tumor microenvironment (TME) influences tumor growth, metastatic spread and
response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …