The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB
proteins have emerged as critical factors that regulate the lineage commitment …

Successful immunity depends upon the activity of multiple cell types. Commitment of
pluripotent precursor cells to specific lineages, such as T or B cells, is obviously fundamental …

The transcription factor PLZF (promyelocytic leukemia zinc finger; zbtb16) is essential for
nearly all of the unique characteristics of NKT cells including their rapid and potent response …

How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The
present study has examined the role in this process of the zinc finger protein Zbtb7b, a …

Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …

Zbtb16-encoded PLZF is a signature transcription factor (TF) that directs the acquisition of T-
helper effector programs during the development of multiple innate lymphocyte lineages …

Cell fate specifications during T lymphocyte differentiation result from the orchestrated
expression of developmentally regulated genes. Furthermore, epigenetic processes that …

The transcription factor PLZF [promyelocytic leukemia zinc finger, encoded by zinc finger
BTB domain containing 16 (Zbtb16)] is induced during the development of innate and innate …

The BTB-ZF (broad-complex, tramtrack and bric-à-brac-zinc finger) proteins are encoded by
at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of …