Neuronal polarization underlies the ability of neurons to integrate and transmit information.
This process begins early in development with axon outgrowth, followed by dendritic growth …

Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the
connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB …

Navigation of retinal projections towards their targets is regulated by guidance molecules
and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences …

Endocannabinoids are retrograde neurotransmitters, which act upon the presynaptically
located, G-protein coupled receptor CB1, to modulate synaptic transmission in the adult …

The type-1 cannabinoid receptor (CB1R) was initially identified as the neuronal target of Δ9-
tetrahydrocannabinol (THC), the major psychoactive substance of marijuana. This receptor …

The roles of endocannabinoid signaling during central nervous system development are
unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal …

The endocannabinoid system plays important roles in brain development, but mechanistic
studies have focused on neuronal differentiation, migration, and synaptogenesis, with less …

Neurons display important differences in plasma membrane composition between
somatodendritic and axonal compartments, potentially leading to currently unexplored …

Endocannabinoids (eCBs) function as retrograde messengers at both excitatory and
inhibitory synapses, and control various forms of synaptic plasticity in the adult brain. The …

The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …