[HTML][HTML] mRNA lipid nanoparticle phase transition
MFW Trollmann, RA Böckmann - Biophysical Journal, 2022 - cell.com
Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid
nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics …
nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics …
Role of ionizable lipids in SARS-CoV-2 vaccines as revealed by molecular dynamics simulations: from membrane structure to interaction with mRNA fragments
M Paloncýová, P Čechová, M Šrejber… - The journal of …, 2021 - ACS Publications
Recent advances in RNA-based medicine have provided new opportunities for the global
current challenge, ie, the COVID-19 pandemic. Novel vaccines are based on a messenger …
current challenge, ie, the COVID-19 pandemic. Novel vaccines are based on a messenger …
Atomistic insights into organization of RNA-loaded lipid nanoparticles
M Paloncýová, M Šrejber, P Čechová… - The Journal of …, 2023 - ACS Publications
RNA-based therapies have shown promise in a wide range of applications, from cancer
therapy, treatment of inherited diseases to vaccination. Encapsulation of RNA into ionizable …
therapy, treatment of inherited diseases to vaccination. Encapsulation of RNA into ionizable …
Elucidation of lipid nanoparticle surface structure in mRNA vaccines
Lipid nanoparticles (LNPs) have been used as a carrier for messenger RNA (mRNA)
vaccines. Surface properties of LNPs are important to the stability and function of mRNA …
vaccines. Surface properties of LNPs are important to the stability and function of mRNA …
A biopharmaceutical perspective on higher-order structure and thermal stability of mRNA vaccines
M Kloczewiak, JM Banks, L Jin… - Molecular …, 2022 - ACS Publications
Preservation of the integrity of macromolecular higher-order structure is a tenet central to
achieving biologic drug and vaccine product stability toward manufacturing, distribution …
achieving biologic drug and vaccine product stability toward manufacturing, distribution …
Deconvoluting lipid nanoparticle structure for messenger RNA delivery
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
Payload distribution and capacity of mRNA lipid nanoparticles
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
Ionizable amino lipids distribution and effects on DSPC/cholesterol membranes: implications for lipid nanoparticle structure
S Dehghani-Ghahnaviyeh, M Smith, Y Xia… - The Journal of …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) containing ionizable aminolipids are among the leading
platforms for the successful delivery of nucleic-acid-based therapeutics, including …
platforms for the successful delivery of nucleic-acid-based therapeutics, including …
[HTML][HTML] mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles
G Tesei, YW Hsiao, A Dabkowska… - Proceedings of the …, 2024 - National Acad Sciences
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent
behavior necessary for an efficient delivery of the cargo—the so-called endosomal escape …
behavior necessary for an efficient delivery of the cargo—the so-called endosomal escape …