Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …

Mitophagy (mitochondrial autophagy) in hepatocytes is an essential quality control
mechanism that removes for lysosomal digestion damaged, effete and superfluous …

Background/Aims An increase of ethanol metabolism and hepatic mitochondrial respiration
occurs in vivo after a single binge of alcohol. Here, our aim was to determine how ethanol …

We have explored the mechanisms underlying ethanol-induced mitochondrial dynamics
disruption and mitophagy. Ethanol increases mitochondrial fission in a concentration …

Alcoholic liver disease (ALD) is a major health problem worldwide, and alcohol is well-
known to cause mitochondrial damage, which exacerbates alcohol-induced liver injury and …

Macroautophagy/autophagy is a dynamic process, and newly synthesized autophagosomes
need to fuse with lysosomes to complete the full process, which is referred to as autophagic …

Mitochondria become targets for autophagic degradation after nutrient deprivation, a
process also termed mitophagy. In this study, we used LysoTracker Red (LTR) and …

Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …

Emerging evidence suggested mitophagy activation mitigates ethanol-induced liver injury.
However, the effect of ethanol on mitophagy is inconsistent. Importantly, the understanding …

Autophagy selectively removes abnormal or damaged organelles such as dysfunctional
mitochondria. The mitochondrial permeability transition (MPT) is a marker of impaired …