The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …

The kidneys are often involved in adverse effects and toxicity caused by exposure to foreign
compounds, chemicals, and drugs. Early predictions of these influences are essential to …

In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …

The staggering cost of bringing a drug to market coupled with the extremely high failure rate
of prospective compounds in early phase clinical trials due to unexpected human toxicity …

The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

The cellular microenvironment is recognized to play a key role in stabilizing cell
differentiation states and phenotypes in culture. This study addresses the hypothesis that …

Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …

Kidney toxicity is one of the most frequent adverse events reported during drug
development. The lack of accurate predictive cell culture models and the unreliability of …

Cell–cell and cell-matrix interactions control cell phenotypes and functions in vivo.
Maintaining these interactions in vitro is essential to both produce and retain cultured cell …