The changes in the properties of three biological events that occur with cerebral aging are
discussed. These adverse changes already begin to develop early in mid-life and gradually …

To develop successful therapies that prevent or treat neurodegenerative diseases requires
an understanding of the upstream events. Ageing is by far the greatest risk factor for most of …

Publisher Summary This chapter describes the key role of mitochondria in energy
transduction in the brain, with particular emphasis on mitochondrial oxidative …

Background: Mitochondria are widely reported to occupy a unique role in modulating cell
viability, senescence and death. This is consistently supported by the multiple functions of …

As a fully differentiated organ, our brain is very sensitive to cumulative oxidative damage of
proteins, lipids, and DNA occurring during normal aging because of its high energy …

Aging is characterized by a progressive decline in the efficiency of physiological function
and by the increased susceptibility to disease and death. The premise of the mitochondrial …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …

Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Normal ageing is associated with a gradual decline in the capacity of various cell types,
including neurones, to respond to metabolic stress and return to the resting state. An …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …