The aim of this study was:(1) to investigate possible role for 5-HT 7 receptors in carrageenan
induced inflammatory paw oedema in rats;(2) to determine the presence of 5-HT 7 receptors …

Abstract Serotonin (5-hydroxytryptamine; 5-HT), a well-characterized neurotransmitter in the
central nervous system, plays a crucial role in regulating mood, body temperature, sleep …

This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and
antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular …

The present study assessed the possible pronociceptive role of peripheral and spinal 5-HT6
receptors in the formalin test. For this, local peripheral administration of selective 5-HT6 …

Brain serotonin 5-HT7 receptors are known to be expressed in neurons and astrocytes. We
now report the presence of these receptors in a third type of cell, microglial cells. 5 …

Abstract In mammalians, serotonin (5-HT) has critical roles in the central nervous system
(CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority …

Background Intestinal inflammation is often associated with an increased level of serotonin
(5-HT), an important gastrointestinal signaling molecule involved in gut homeostasis through …

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by
highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and …

Abstract The neurotransmitter 5-hydroxytryptamine (5-HT), commonly known as serotonin, is
released at peripheral sites from activated enterochromaffin cells, mast cells and platelets. In …

Although typically considered a neurotransmitter, there is substantial evidence that serotonin
(5-HT) plays an important role in the pathogenesis of inflammatory disorders. Despite these …