Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13
S Liu, RF Sommese, NL Nedoma, LM Stevens… - Nature …, 2023 - nature.com
Abstract Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-
associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease …
associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease …
Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity
Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid
dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease …
dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease …
Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
W Su, S Wu, Y Yang, Y Guo, H Zhang, J Su… - Nature …, 2022 - nature.com
Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
Role of HSD17B13 in the liver physiology and pathophysiology
W Su, Z Mao, Y Liu, X Zhang, W Zhang… - Molecular and cellular …, 2019 - Elsevier
Abstract 17β-Hydroxysteroid dehydrogenases (HSD17Bs) comprise a large family of 15
members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes …
members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes …
Identification and characterization of the ER/lipid droplet-targeting sequence in 17β-hydroxysteroid dehydrogenase type 11
Y Horiguchi, M Araki, K Motojima - Archives of biochemistry and biophysics, 2008 - Elsevier
17β-Hydroxysteroid dehydrogenase type 11 (17βHSD11) is mostly localized on the
endoplasmic reticulum (ER) membrane under normal conditions and redistributes to lipid …
endoplasmic reticulum (ER) membrane under normal conditions and redistributes to lipid …
[PDF][PDF] 17‐beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A
single‐nucleotide polymorphism (SNP), rs6834314, was associated with serum liver …
single‐nucleotide polymorphism (SNP), rs6834314, was associated with serum liver …
17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease
MX Wang, ZG Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic and a major
public health problem, with a prevalence of approximately 25%. The pathogenesis of …
public health problem, with a prevalence of approximately 25%. The pathogenesis of …
17β-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein
Y Horiguchi, M Araki, K Motojima - Biochemical and biophysical research …, 2008 - Elsevier
17β-Hydroxysteroid dehydrogenase (17βHSD) type 13 is identified as a new lipid droplet-
associated protein. 17βHSD type 13 has an N-terminal sequence similar to that of 17βHSD …
associated protein. 17βHSD type 13 has an N-terminal sequence similar to that of 17βHSD …
Down-regulating the high level of 17-beta-hydroxysteroid dehydrogenase 13 plays a therapeutic role for non-alcoholic fatty liver disease
M Wang, J Li, H Li, B Dong, J Jiang, N Liu… - International Journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and there is no specific drug to treat it. Recent results showed that 17-beta …
worldwide, and there is no specific drug to treat it. Recent results showed that 17-beta …
Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
W Su, Y Wang, X Jia, W Wu, L Li… - Proceedings of the …, 2014 - National Acad Sciences
Nonalcoholic fatty liver disease (NAFLD) is characterized by a massive accumulation of lipid
droplets (LDs). The aim of this study was to determine the function of 17β-hydroxysteroid …
droplets (LDs). The aim of this study was to determine the function of 17β-hydroxysteroid …