[HTML][HTML] Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
[HTML][HTML] Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …
[HTML][HTML] Phase separation in biology and disease; current perspectives and open questions
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …
existence, formation, biological functions, and disease associations of membraneless …
[HTML][HTML] CD-CODE: crowdsourcing condensate database and encyclopedia
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
Biomolecular condensates in neurodegeneration and cancer
S Spannl, M Tereshchenko, GJ Mastromarco, SJ Ihn… - Traffic, 2019 - Wiley Online Library
The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …
containing specific sets of molecules and reactions. Biomolecular condensates, also …
[PDF][PDF] Biomolecular condensates and cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …
have been the subject of detailed genetic, biochemical, and structural studies, but only …
Learning the chemical grammar of biomolecular condensates
HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
Biomolecular condensates and their links to cancer progression
Liquid–liquid phase separation (LLPS) has emerged in recent years as an important
physicochemical process for organizing diverse processes within cells via the formation of …
physicochemical process for organizing diverse processes within cells via the formation of …
A framework for understanding the functions of biomolecular condensates across scales
AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
Synthetic protein condensates for cellular and metabolic engineering
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …
molecules via phase separation in a confined subcellular compartment. In the past decade …