[HTML][HTML] Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

[HTML][HTML] Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics

BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

[HTML][HTML] Phase separation in biology and disease; current perspectives and open questions

S Boeynaems, S Chong, J Gsponer, L Holt… - Journal of molecular …, 2023 - Elsevier
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …

[HTML][HTML] CD-CODE: crowdsourcing condensate database and encyclopedia

N Rostam, S Ghosh, CFW Chow, A Hadarovich… - Nature …, 2023 - nature.com
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …

Biomolecular condensates in neurodegeneration and cancer

S Spannl, M Tereshchenko, GJ Mastromarco, SJ Ihn… - Traffic, 2019 - Wiley Online Library
The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …

[PDF][PDF] Biomolecular condensates and cancer

A Boija, IA Klein, RA Young - Cancer cell, 2021 - cell.com
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

Learning the chemical grammar of biomolecular condensates

HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

Biomolecular condensates and their links to cancer progression

D Cai, Z Liu, J Lippincott-Schwartz - Trends in biochemical sciences, 2021 - cell.com
Liquid–liquid phase separation (LLPS) has emerged in recent years as an important
physicochemical process for organizing diverse processes within cells via the formation of …

A framework for understanding the functions of biomolecular condensates across scales

AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Synthetic protein condensates for cellular and metabolic engineering

ZG Qian, SC Huang, XX Xia - Nature Chemical Biology, 2022 - nature.com
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …