DNA damage from sulfite autoxidation catalyzed by a nickel (II) peptide

JG Muller, RP Hickerson, RJ Perez… - Journal of the American …, 1997 - ACS Publications
Guanine-specific modification of both single-and double-stranded oligodeoxynucleotides via
the autoxidation of sulfite is shown to be catalyzed by [NiCR] 2+(where CR= 2, 12-dimethyl …

Metal-mediated oxidation of guanines in DNA and RNA: a comparison of cobalt (II), nickel (II) and copper (II) complexes

GA McLachlan, JG Muller, SE Rokita… - Inorganica Chimica Acta, 1996 - Elsevier
Nickel (II) complexes of certain strong field tetradentate ligands have been found to mediate
guanine-specific modification of DNA and RNA in the presence of the strong oxidant …

Metallodrug complexes that mediate DNA and lipid damage via sulfite autoxidation: copper (II) famotidine and iron (III) bis (salicyglycine)

JG Muller, CJ Burrows - Inorganica chimica acta, 1998 - Elsevier
Random DNA damage via the autoxidation of sulfite is observed to be mediated by
micromolar concentrations of copper (II) and iron (III) metallodrug complexes. Importantly …

DNA and RNA Modification Promoted by [Co(H2O)6]Cl2 and KHSO5:  Guanine Selectivity, Temperature Dependence, and Mechanism

JG Muller, P Zheng, SE Rokita… - Journal of the American …, 1996 - ACS Publications
Reaction of a single-stranded oligodeoxynucleotide or a 17-base hairpin-forming
oligodeoxynucleotide with CoCl2 and KHSO5 produced guanine-specific cleavage after …

DNA modification: intrinsic selectivity of nickel (II) complexes

X Chen, SE Rokita, CJ Burrows - Journal of the American …, 1991 - ACS Publications
Oligonucleotides were chosen for study since they are small enough to permit a detailed
study of reaction products yet large enough to display the base specificity for nucleotide …

Site-specific DNA damage induced by sulfite in the presence of cobalt (II) ion: Role of sulfate radical

K Shosuke, Y Koji, I Sumiko - Biochemical pharmacology, 1989 - Elsevier
The reactivities of sulfite (SO 3 2−) with DNA in the presence of metal ions were investigated
by a DNA sequencing technique using 32 P-labeled DNA fragments obtained from human c …

Mechanistic information on the redox cycling of nickel (II/III) complexes in the presence of sulfur oxides and oxygen. Correlation with DNA damage experiments

V Lepentsiotis, J Domagala, I Grgic… - Inorganic …, 1999 - ACS Publications
The reactions of the water-soluble complexes [NiCR] 2+(where CR= 2, 12-dimethyl-3, 7, 11,
17-tetraazabicyclo [11.3. 1] heptadeca-1 (17), 2, 11, 13, 15-pentaene) and [NiKGH …

Ligand effects associated with the intrinsic selectivity of DNA oxidation promoted by nickel (II) macrocyclic complexes

JG Muller, X Chen, AC Dadiz, SE Rokita… - Journal of the …, 1992 - ACS Publications
Nickel (II)-promoted oxidation of accessible guanine residues in deoxyoligonucleotides
using KHSOs as oxidant was found to be highly dependent upon the macrocyclic ligand …

Artificial nucleases

CB Chen, L Milne, R Landgraf, DM Perrin… - …, 2001 - Wiley Online Library
The oxidation of DNA and RNA provides a facile approach for investigating the interaction of
nucleic acids with proteins and oligonucleotides. In this article, we have outlined our …

Nickel-dependent oxidative cross-linking of a protein

G Gill, AA Richter-Rusli, M Ghosh… - Chemical research in …, 1997 - ACS Publications
A model protein, ribonuclease A (bovine pancreas), was examined for its ability to
coordinate Ni2+ and promote selective oxidation. In the presence of a peracid such as …