Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …

Elements of the immune system particularly that of innate immunity, play important roles
beyond their traditional tasks in host defense, including manifold roles in the nervous …

The diagnosis of neurodegenerative disorders is often challenging due to the lack of
diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction …

Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Introduction Synapse dysfunction is emerging as an early pathological event in
frontotemporal dementia (FTD), however biomarkers are lacking. We aimed to investigate …

Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of
synapses. Here, we present findings supporting a special role for excitatory synapses …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

Objective This study examined whether cerebrospinal fluid (CSF) baseline levels of the
synaptic protein NPTX2 predict time to onset of symptoms of mild cognitive impairment …

Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the
signaling pathways governing NFκB regulation and function in the brain are poorly …

Accumulation of amyloid-β (Aβ) is thought to play a central role in the progressive loss of
synapses, the neurite damage, and the neuronal death that are characteristic in brains …