Hypothermic circulatory arrest is a protective technique used when complete cessation of
circulation is required during cardiac surgery. Prior efforts to decrease neurologic injury with …

Aims The objective of this article is to summarize the state of the literature surrounding the
use of ketamine as a neuroprotective agent following cardiac arrest. Methods Five electronic …

Central nervous system dysfunction continues to represent significant morbidity and
associated mortality in patients undergoing cardiac surgery. Neurological dysfunction is …

Background. Central nervous system dysfunction continues to produce significant morbidity
and associated mortality in patients undergoing cardiac surgery. Using a closed-chest …

NEUROPROTECTION MAY BE DEFINED AS the “pre-vention or amelioration of neuronal
damage evidenced by abnormalities in cerebral metabolism, histopathology or neurologic …

BACKGROUND: Prolonged hypothermic circulatory arrest results in neuronal cell death and
neurologic injury. We have previously shown that hypothermic circulatory arrest causes both …

Background. Neurologic injury, including choreoathetosis and learning and memory deficits,
occurs after prolonged hypothermic circulatory arrest (HCA). Apoptosis, or programmed cell …

BACKGROUND: The effects of pretreatment with cariporide (HOE 642 Aventis Pharma,
Strasbourg-Cedex, France), a Na+–H+ exchanger (NHE) blocker, were studied in a cerebral …

BACKGROUND.: Although hypothermic circulatory arrest (HCA) has become routine
practice in cardiac surgery, it is associated with substantial neurotoxicity. We tested the …

Background: Glutamate excitotoxicity has an important role in the development of brain
injury after prolonged hypothermic circulatory arrest. The goal of the present studies was to …