Molecular mechanism and inhibitory targets of dioscin in HepG2 cells

YS Zhang, YL Ma, K Thakur, SS Hussain… - Food and Chemical …, 2018 - Elsevier
Dioscin has been known for its anti-cancer activity; however, its detailed molecular
mechanisms have not been studied so far. Herein, we evaluated the anti-cancer activity of …

Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

G Zhang, X Zeng, R Zhang, J Liu, W Zhang, Y Zhao… - Phytomedicine, 2016 - Elsevier
Background Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy
of the liver, occurs frequently in the setting of chronic liver injury. Although multiple …

Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway

Y Wei, Y Xu, X Han, Y Qi, L Xu, Y Xu, L Yin… - Food and chemical …, 2013 - Elsevier
Dioscin, a natural steroid saponin, has been widely investigated. However, its anti-cancer
activities on human lung cancer cells are still unknown. In the present paper, the inhibitory …

Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways

S Li, B Cheng, L Hou, L Huang, Y Cui, D Xu… - Anti-Cancer …, 2018 - journals.lww.com
Dioscin is a natural steroid saponin derived from several plants that shows potent anticancer
effects against a variety of cancer cells. Here, we investigated the antitumor effect of dioscin …

Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways

M Hu, L Xu, L Yin, Y Qi, H Li, Y Xu… - Journal of Applied …, 2013 - Wiley Online Library
In the present study, the antiproliferative effect of dioscin on human gastric carcinoma SGC‐
7901 cells was confirmed by 3‐(4, 5‐dimethylthiahiazo‐zyl)‐2, 5‐dip‐henytetrazolium …

Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway

XL Li, RH Ma, ZJ Ni, K Thakur… - Food and Chemical …, 2021 - Elsevier
The present study emphasized on the anti-cancerous effects of dioscin and its underlying
molecular mechanism in human endometrial cancer Ishikawa cells. Dioscin significantly …

Potent effects of dioscin against gastric cancer in vitro and in vivo

X Zhao, L Xu, L Zheng, L Yin, Y Qi, X Han, Y Xu, J Peng - Phytomedicine, 2016 - Elsevier
Background We previously reported the effect of dioscin on human gastric carcinoma SGC-
7901 cells, but its effects on other gastric cancers are still unknown. Purpose The present …

Potent effects of dioscin against hepatocellular carcinoma through regulating TP53‐induced glycolysis and apoptosis regulator (TIGAR)‐mediated apoptosis …

Z Mao, X Han, D Chen, Y Xu, L Xu, L Yin… - British journal of …, 2019 - Wiley Online Library
Background and purpose Dioscin shows potent effects against cancers. We aimed to
elucidate its pharmacological effects and mechanisms of action on hepatocellular carcinoma …

Antitumor effects of dioscin in A431 cells via adjusting ATM/p53‑mediated cell apoptosis, DNA damage and migration

P Wang, C Wang, C Liu - Oncology letters, 2021 - spandidos-publications.com
Skin cancer is the deadliest type of malignant disease and causes primary mortality
worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However …

Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of …

L Si, L Zheng, L Xu, L Yin, X Han, Y Qi, Y Xu… - European journal of …, 2016 - Elsevier
The anti-cancer effects of dioscin have been widely reported. However, its effect on
laryngeal cancer remains unknown. In the present paper, our results showed that dioscin …