Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization

MJ Gómez-Torres, EM García, J Guerrero… - Reproductive Biology …, 2015 - Springer
Background Fertilization is a key physiological process for the preservation of the species.
Consequently, different mechanisms affecting the sperm and the oocyte have been …

Metabolomics analysis of human cumulus cells obtained from cumulus–oocyte complexes with different developmental potential

Á Martínez-Moro, L González-Brusi… - Human …, 2023 - academic.oup.com
STUDY QUESTION Is the abundance of certain biochemical compounds in human cumulus
cells (CCs) related to oocyte quality? SUMMARY ANSWER Malonate, 5-oxyproline, and …

Conditioned medium from human cumulus oophorus cells stimulates human sperm velocity

PM Fetterolf, A Jurisicova, JE Tyson… - Biology of …, 1994 - academic.oup.com
The objective of this study was to determine whether the cumulus oophorus cells
surrounding the human oocyte release a factor (s) that stimulates sperm velocity. Medium …

The differential metabolomes in cumulus and mural granulosa cells from human preovulatory follicles

EM Gao, B Turathum, L Wang, D Zhang, YB Liu… - Reproductive …, 2022 - Springer
This study evaluated the differences in metabolites between cumulus cells (CCs) and mural
granulosa cells (MGCs) from human preovulatory follicles to understand the mechanism of …

Function of the cumulus oophorus before and during mammalian fertilization

A Van Soom, S Tanghe, I De Pauw… - … in Domestic Animals, 2002 - Wiley Online Library
Contents Fertilization encompasses a series of different steps which have to be performed in
a well‐orchestrated way to create a new individual. They include sperm capacitation, sperm …

RANTES and human sperm fertilizing ability: effect on acrosome reaction and sperm/oocyte fusion

A Barbonetti, MRC Vassallo… - Molecular human …, 2008 - academic.oup.com
Abstract β-Chemokine, regulated on activation and normally T-cell expressed and
presumably secreted (RANTES), is present in both the male and female genital tract fluids …

The sperm chemoattractant secreted from human cumulus cells is progesterone

R Oren-Benaroya, R Orvieto, A Gakamsky… - Human …, 2008 - academic.oup.com
BACKGROUND Human spermatozoa appear to be guided by chemotaxis to the oocyte in
the female genital tract. While one of the sources of sperm chemoattractants is the cumulus …

Follicular factors influence oocyte fertilizability by modulating the intercellular cooperation between cumulus cells and oocyte

M Mattioli, G Galeati, ML Bacci, E Seren - Gamete Research, 1988 - Wiley Online Library
In order to investigate whether the follicular tissue influences cumulus‐oocyte interaction
and, consequently, the fertilizability of the egg, four experiments were carried out. In the first …

Molecular and Cellular Mechanisms of Sperm-Oocyte Interactions Opinions Relative to in Vitro Fertilization (IVF)

G Anifandis, C Messini, K Dafopoulos… - International journal of …, 2014 - mdpi.com
One of the biggest prerequisites for pregnancy is the fertilization step, where a human
haploid spermatozoon interacts and penetrates one haploid oocyte in order to produce the …

The secretion and metabolism of cumulus cells support fertilization in the bovine model

Y Kato, Y Ohshima, A Sasaki, E Yoshikawa, H Xu… - Theriogenology, 2022 - Elsevier
The cumulus oophorus is a structure that surrounds the mammalian egg and plays a key
role in fertilization. However, very little is known with regards to how secretions from the …