Simultaneous carbon catabolite repression governs sugar and aromatic co-utilization in Pseudomonas putida M2

S Shrestha, D Awasthi, Y Chen, J Gin… - Applied and …, 2023 - Am Soc Microbiol
Pseudomonas putida have emerged as promising biocatalysts for the conversion of sugars
and aromatic compounds obtained from lignocellulosic biomass. Understanding the role of …

Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in Pseudomonas putida KT2440

CW Johnson, PE Abraham, JG Linger, P Khanna… - Metabolic engineering …, 2017 - Elsevier
Carbon catabolite repression refers to the preference of microbes to metabolize certain
growth substrates over others in response to a variety of regulatory mechanisms. Such …

Multi-omics analysis unravels a segregated metabolic flux network that tunes co-utilization of sugar and aromatic carbons in Pseudomonas putida

MA Kukurugya, CM Mendonca, M Solhtalab… - Journal of Biological …, 2019 - ASBMB
Pseudomonas species thrive in different nutritional environments and can catabolize
divergent carbon substrates. These capabilities have important implications for the role of …

The Crc/CrcZ‐CrcY global regulatory system helps the integration of gluconeogenic and glycolytic metabolism in Pseudomonas putida

R La Rosa, J Nogales, F Rojo - Environmental microbiology, 2015 - Wiley Online Library
In metabolically versatile bacteria, carbon catabolite repression (CCR) facilitates the
preferential assimilation of the most efficient carbon sources, improving growth rates and …

A cyclic metabolic network in Pseudomonas protegens Pf-5 prioritizes the Entner-Doudoroff pathway and exhibits substrate hierarchy during carbohydrate co …

RA Wilkes, CM Mendonca… - Applied and environmental …, 2019 - Am Soc Microbiol
The genetic characterization of Pseudomonas protegens Pf-5 was recently completed.
However, the inferred metabolic network structure has not yet been evaluated …

Revealing oxidative pentose metabolism in new Pseudomonas putida isolates

MR Park, R Gauttam, B Fong, Y Chen… - Environmental …, 2023 - Wiley Online Library
The Pseudomonas putida group in the Gammaproteobacteria has been intensively studied
for bioremediation and plant growth promotion. Members of this group have recently …

Rewiring the functional complexity between Crc, Hfq and sRNAs to regulate carbon catabolite repression in Pseudomonas

K Bharwad, S Rajkumar - World Journal of Microbiology and …, 2019 - Springer
Pseudomonas species are the most versatile of all known bacteria for metabolic flexibility
and the extent of host range from plants to humans that remains unmatched. The evolution …

Analysis of Pseudomonas putida growth on non‐trivial carbon sources using transcriptomics and genome‐scale modelling

I D'Arrigo, JGR Cardoso, M Rennig… - Environmental …, 2019 - Wiley Online Library
Pseudomonas putida is characterized by a versatile metabolism and stress tolerance traits
that allow the bacterium to cope with different environmental conditions. In this work, the …

When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α, ω-diols in …

C Lu, C Batianis, EO Akwafo, RH Wijffels… - Biotechnology for …, 2021 - Springer
Background Medium-chain-length α, ω-diols (mcl-diols) are important building blocks in
polymer production. Recently, microbial mcl-diol production from alkanes was achieved in E …

Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion

AD Flores, GL Kurgan, X Wang - … of microorganisms for the production of …, 2017 - Springer
Lignocellulosic biomass represents a renewable domestic feedstock that can support large-
scale biochemical production processes for fuels and specialty chemicals. However, cost …