Genome binning of viral entities from bulk metagenomics data

J Johansen, DR Plichta, JN Nissen… - Nature …, 2022 - nature.com
Despite the accelerating number of uncultivated virus sequences discovered in
metagenomics and their apparent importance for health and disease, the human gut virome …

Phage-inclusive profiling of human gut microbiomes with Phanta

Y Pinto, M Chakraborty, N Jain, AS Bhatt - Nature Biotechnology, 2024 - nature.com
Due to technical limitations, most gut microbiome studies have focused on prokaryotes,
overlooking viruses. Phanta, a virome-inclusive gut microbiome profiling tool, overcomes the …

Improved metagenome binning and assembly using deep variational autoencoders

JN Nissen, J Johansen, RL Allesøe, CK Sønderby… - Nature …, 2021 - nature.com
Despite recent advances in metagenomic binning, reconstruction of microbial species from
metagenomics data remains challenging. Here we develop variational autoencoders for …

Metaviral SPAdes: assembly of viruses from metagenomic data

D Antipov, M Raiko, A Lapidus, PA Pevzner - Bioinformatics, 2020 - academic.oup.com
Motivation Although the set of currently known viruses has been steadily expanding, only a
tiny fraction of the Earth's virome has been sequenced so far. Shotgun metagenomic …

DeePhage: distinguishing virulent and temperate phage-derived sequences in metavirome data with a deep learning approach

S Wu, Z Fang, J Tan, M Li, C Wang, Q Guo, C Xu… - …, 2021 - academic.oup.com
Background Prokaryotic viruses referred to as phages can be divided into virulent and
temperate phages. Distinguishing virulent and temperate phage–derived sequences in …

VirFinder: a novel k-mer based tool for identifying viral sequences from assembled metagenomic data

J Ren, NA Ahlgren, YY Lu, JA Fuhrman, F Sun - Microbiome, 2017 - Springer
Background Identifying viral sequences in mixed metagenomes containing both viral and
host contigs is a critical first step in analyzing the viral component of samples. Current tools …

CONCOCT: clustering contigs on coverage and composition

J Alneberg, BS Bjarnason, I de Bruijn… - arXiv preprint arXiv …, 2013 - arxiv.org
Metagenomics enables the reconstruction of microbial genomes in complex microbial
communities without the need for culturing. Since assembly typically results in fragmented …

Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut

R Li, Y Wang, H Hu, Y Tan, Y Ma - Nature Communications, 2022 - nature.com
The human gut microbiome has been extensively explored, while the archaeal viruses
remain largely unknown. Here, we present a comprehensive analysis of the archaeal …

VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences

K Kieft, Z Zhou, K Anantharaman - Microbiome, 2020 - Springer
Background Viruses are central to microbial community structure in all environments. The
ability to generate large metagenomic assemblies of mixed microbial and viral sequences …

vRhyme enables binning of viral genomes from metagenomes

K Kieft, A Adams, R Salamzade, L Kalan… - Nucleic Acids …, 2022 - academic.oup.com
Genome binning has been essential for characterization of bacteria, archaea, and even
eukaryotes from metagenomes. Yet, few approaches exist for viruses. We developed …