Nutrient-limiting conditions are common during cancer development. The coordination of
cellular glucose levels and cell survival is a fundamental question in cell biology and has not …

F-box/LRR-repeat protein 7 (FBXL7) was predicted as a differentially expressed E3 ubiquitin
ligase in non-small cell lung cancer (NSCLC), which has been suggested to influence …

Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism.
Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose …

Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic
agents and induce cell death during glucose deprivation, a cell condition that occurs in the …

Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …

Mammalian Eps15 homology domain 1 (EHD1) participates in the development of non-small
cell lung cancer (NSCLC). However, its role in mediating aerobic glycolysis remains unclear …

Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a
common feature of aggressive cancer cells and can be targeted. However, metabolic …

Metabolic reprogramming in cancer cells can create metabolic liabilities. KEAP1-mutant
lung cancer is refractory to most current therapies. Here we show that KEAP1 deficiency …

Background: Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (4EBP1) involved
in inhibition of protein translation and synthesis. However, the phosphoprotein of 4EBP1 (p …

Non-small cell lung cancer (NSCLC) accompanied by diabetes is an important risk factor
affecting the prognosis of patients with NSCLC in clinical practice. However, the effect of …