The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

Many cancer types metastasize to bone. This propensity may be a product of genetic traits of
the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Some of the most common cancer types, including breast cancer, prostate cancer, and lung
cancer, show a predilection to metastasize to bone. The molecular basis of this preferential …

Bone metastasis, or the development of secondary tumors within the bone of cancer
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …

During the past decade preclinical studies have defined many of the mechanisms used by
tumours to hijack the skeleton and promote bone metastasis. This has led to the …

The bone microenvironment provides a fertile soil for cancer cells. It is therefore not
surprising that the skeleton is a frequent site of cancer metastasis. It is believed that …

It has long been recognized that primary cancers spread to distant organs with characteristic
preference. Bone metastases occur in∼ 70% of patients with advanced breast and prostate …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

Bone, as well as lung and liver, is one of the most preferential metastatic target sites for
cancers including breast, prostate, and lung cancers. Although the precise molecular …