Borate bioactive glass prevents zoledronate‐induced osteonecrosis of the jaw by restoring osteogenesis and angiogenesis

Z Su, J Li, X Bai, FR Tay, M Zhang, K Liang, L He… - Oral …, 2020 - Wiley Online Library
Objectives Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe
complication of systemic nitrogen‐containing bisphosphonate (N‐BP) administration, which …

[HTML][HTML] Beta-adrenergic receptor antagonist propranolol prevents bisphosphonate-related osteonecrosis of the jaw by promoting osteogenesis

Q Du, Q Wang, Y Wang, C Zhao, J Pan - Journal of Dental Sciences, 2024 - Elsevier
Background/purpose Bisphosphonate-related osteonecrosis of the jaw (BRONJ), a
complication arising from the use of bisphosphonates (BPs), inflicts long-term suffering on …

PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis

S Gao, R Lin, S Huang, Y Liang, X Li, S Zhang… - Bone, 2021 - Elsevier
The mechanism and effective treatment of bisphosphonate-related osteonecrosis of the jaw
(BRONJ) are still uncertain. Our previous study revealed that zoledronate (ZOL) …

Revival of nitrogen-containing bisphosphonate-induced inhibition of osteoclastogenesis and osteoclast function by water-soluble microfibrous borate glass

H Yuan, L Niu, K Jiao, D Pei, C Pramanik, J Li… - Acta biomaterialia, 2016 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious skeletal complication
associated with the long-term oral or intravenous use of nitrogen-containing …

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB

S Gao, G Zheng, L Wang, Y Liang, S Zhang, X Lao… - PloS one, 2017 - journals.plos.org
Purpose Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of
systemic BPs administration, the mechanism of which is still unclarified. Recently, platelet …

Impact of beta-tricalcium phosphate on preventing tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaw in rats

N Funayama, T Yagyuu, M Imada, Y Ueyama… - Scientific Reports, 2023 - nature.com
Antiresorptive or antiangiogenic drugs can cause medication-related osteonecrosis of the
jaw that is refractory. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) may be …

Introducing a protocol to create bisphosphonate-related osteonecrosis of the jaw in rat animal model

M Zandi, A Dehghan, H Malekzadeh, P Janbaz… - Journal of Cranio …, 2016 - Elsevier
Objective Previously published animal investigations on bisphosphonate-related
osteonecrosis of the jaws (BRONJ) showed a variety of methods for BRONJ induction and …

[HTML][HTML] A novel model of bisphosphonate-related osteonecrosis of the jaw in rats

H Yang, H Pan, F Yu, K Chen, G Shang… - International journal of …, 2015 - ncbi.nlm.nih.gov
Objective: To establish a rat model of bisphosphonate-related osteonecrosis of the jaw
(BRONJ) that realistically mimics major clinical manifestations of the disease. Methods …

Impact of soft tissue pathophysiology in the development and maintenance of bisphosphonate-related osteonecrosis of the jaw (BRONJ)

T Ziebart, F Halling, P Heymann, A Neff, S Blatt, J Jung… - Dentistry Journal, 2016 - mdpi.com
Since the first description of bisphosphonate-related osteonecrosis of the jaw (BRONJ),
numerous research groups have focused on possible pathological mechanisms including …

Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells

C Walter, MO Klein, A Pabst, B Al-Nawas… - Clinical oral …, 2010 - Springer
Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in
patients receiving highly potent nitrogen-containing bisphosphonates. The exact …