Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA
N Schwab - Brain, 2024 - academic.oup.com
Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA
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Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis
Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …
relatively little is known about the precise nature of the immune dysregulation underlying the …
Integrated single-cell transcriptomics of cerebrospinal fluid cells in treatment-naïve multiple sclerosis
Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …
CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes
ML Elkjaer, A Nawrocki, T Kacprowski, P Lassen… - Scientific reports, 2021 - nature.com
To identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step
proteomic approach:(i) Discovery proteomics compared 169 pooled CSF from MS subtypes …
proteomic approach:(i) Discovery proteomics compared 169 pooled CSF from MS subtypes …
Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown.
Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis …
Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis …
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
C Barbour, P Kosa, M Varosanec, M Greenwood… - medRxiv, 2020 - medrxiv.org
The inability to measure putative pathogenic processes in the central nervous system (CNS)
of living subjects precludes the determination of their temporal distribution, intra-individual …
of living subjects precludes the determination of their temporal distribution, intra-individual …
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
GY Zheleznyakova, E Piket… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central
nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs …
nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs …
Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple Sclerosis
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous
system, marked by inflammation, demyelination, and neurodegeneration. Diagnosis is …
system, marked by inflammation, demyelination, and neurodegeneration. Diagnosis is …
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis
R Magliozzi, OW Howell, R Nicholas… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) damage and meningeal inflammation have been associated
with early disease onset and a more aggressive disease course in multiple sclerosis (MS) …
with early disease onset and a more aggressive disease course in multiple sclerosis (MS) …
Molecular biomarkers in cerebrospinal fluid of multiple sclerosis patients
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system,
usually occurring in young adults and leading to disability. Despite the progress in …
usually occurring in young adults and leading to disability. Despite the progress in …