Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA

N Schwab - Brain, 2024 - academic.oup.com
Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA
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Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis

M Ban, D Bredikhin, Y Huang, MJ Bonder, K Katarzyna… - Brain, 2024 - academic.oup.com
Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …

Integrated single-cell transcriptomics of cerebrospinal fluid cells in treatment-naïve multiple sclerosis

F Straeten, J Zhu, AL Börsch, B Zhang, K Li… - Journal of …, 2022 - Springer
Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …

CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

ML Elkjaer, A Nawrocki, T Kacprowski, P Lassen… - Scientific reports, 2021 - nature.com
To identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step
proteomic approach:(i) Discovery proteomics compared 169 pooled CSF from MS subtypes …

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

EF Mosleth, CA Vedeler, KH Liland, A McLeod… - Scientific Reports, 2021 - nature.com
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown.
Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis …

Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms

C Barbour, P Kosa, M Varosanec, M Greenwood… - medRxiv, 2020 - medrxiv.org
The inability to measure putative pathogenic processes in the central nervous system (CNS)
of living subjects precludes the determination of their temporal distribution, intra-individual …

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

GY Zheleznyakova, E Piket… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central
nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs …

Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple Sclerosis

S Sayad, M Hiatt, H Mustafa - medRxiv, 2024 - medrxiv.org
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous
system, marked by inflammation, demyelination, and neurodegeneration. Diagnosis is …

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

R Magliozzi, OW Howell, R Nicholas… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) damage and meningeal inflammation have been associated
with early disease onset and a more aggressive disease course in multiple sclerosis (MS) …

Molecular biomarkers in cerebrospinal fluid of multiple sclerosis patients

B Fitzner, M Hecker, UK Zettl - Autoimmunity reviews, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system,
usually occurring in young adults and leading to disability. Despite the progress in …