The inflammatory response plays out over time in a reproducible and organized way after an
initiating stimulus. Here we show that genes activated in cultured mouse fibroblasts in …

The anti-inflammatory cytokines IL-4 and IL-10 are well recognized as important negative
regulators of proinflammatory gene expression in mononuclear phagocytes. The …

The inflammatory response is a complex physiologic process that requires the coordinate
induction of cytokines, chemokines, angiogenic factors, effector‐enzymes, and proteases …

The expression of genes involved in the inflammatory response is controlled both
transcriptionally and post-transcriptionally. Primary inflammatory stimuli, such as microbial …

The inflammatory response requires the activation of a complex transcriptional program that
is both cell-type-and stimulus-specific and involves the dynamic regulation of hundreds of …

Transcriptional control mechanisms chart the course of the inflammatory response by
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …

The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …

The kinetics and magnitude of cytokine gene expression are tightly regulated to elicit a
balanced response to pathogens and result from integrated changes in transcription and …

Enhancers determine tissue-specific gene expression programs. Enhancers are marked by
high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300 …

When cells are induced to express inflammatory genes by treatment with TNF, the mRNAs
for the induced genes appear in three distinct waves, defining gene groups I, II, and III, or …