Signaling through the interleukin‐4/interleukin‐13 (IL‐4/IL‐13) receptor complex is a crucial
mechanism in the development of bronchial asthma and chronic obstructive pulmonary …

Abstract Interleukin-13 (IL13) is a major player in the development of airway
hyperresponsiveness in several respiratory disorders. Emerging data suggest that an …

Excessive production of airway mucus is a cardinal feature of bronchial asthma and chronic
obstructive pulmonary disease (COPD) and contributes to morbidity and mortality in these …

Mucus production is a cardinal feature of bronchial asthma, contributing to morbidity and
mortality in the disease. Goblet cells are major mucus-producing cells, and goblet cell …

LETTERS TO THE EDITOR 1425 activity than the recently identified pendrin inhibitors,
PDSinh-A01 and PDSinh-C01 (see Fig E1, DI). 6 YS-01 inhibited both human and mouse …

The epithelium plays an active role in the response to inhaled pathogens in part by
responding to signals from the immune system. Epithelial responses may include changes …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …

Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However,
recent data support the linkage between pendrin expression and airway diseases, such as …

Asthma exacerbations can be triggered by viral infections or allergens. The Th2 cytokines IL-
13 and IL-4 are produced during allergic responses and cause increases in airway epithelial …

Background Chronic rhinosinusitis (CRS) is a multifactorial disease of unknown cause
characterized by sinonasal inflammation, increased mucus production, and defective …