Aquaporin 4‐specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter
M Varrin‐Doyer, CM Spencer… - Annals of …, 2012 - Wiley Online Library
Abstract Objective: Aquaporin 4 (AQP4)‐specific autoantibodies in neuromyelitis optica
(NMO) are immunoglobulin (Ig) G1, a T cell‐dependent Ig subclass, indicating that AQP4 …
(NMO) are immunoglobulin (Ig) G1, a T cell‐dependent Ig subclass, indicating that AQP4 …
[HTML][HTML] The gut microbiome in neuromyelitis optica
Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system
inflammatory demyelinating disease that is associated with antibodies (“NMO IgG”) that …
inflammatory demyelinating disease that is associated with antibodies (“NMO IgG”) that …
[HTML][HTML] Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance
Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …
[HTML][HTML] Neuromyelitis optica pathogenesis and aquaporin 4
DJ Graber, M Levy, D Kerr, WF Wade - Journal of neuroinflammation, 2008 - Springer
Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly
features immunopathology in the optic nerves and the spinal cord. An IgG1 autoantibody …
features immunopathology in the optic nerves and the spinal cord. An IgG1 autoantibody …
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica
Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal
cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably …
cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably …
[HTML][HTML] Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica
S Mader, A Lutterotti, F Di Pauli, B Kuenz, K Schanda… - PloS one, 2010 - journals.plos.org
Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself
with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG …
with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG …
Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica
SR Kalluri, Z Illes, R Srivastava, B Cree… - Archives of …, 2010 - jamanetwork.com
Background Antibodies targeting membrane proteins play an important role in various
autoimmune diseases of the nervous system. So far, assays allowing proper analysis of …
autoimmune diseases of the nervous system. So far, assays allowing proper analysis of …
[HTML][HTML] T cell-activation in neuromyelitis optica lesions plays a role in their formation
Background Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the
central nervous system (CNS), which is characterized by the presence of pathogenic serum …
central nervous system (CNS), which is characterized by the presence of pathogenic serum …
Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica
R Wilson, M Makuch, AK Kienzler, J Varley, J Taylor… - Brain, 2018 - academic.oup.com
Abstract Autoantibodies to aquaporin-4 (AQP4) are pathogenic in neuromyelitis optica
spectrum disorder (NMOSD). However, it is not known which B cells are the major …
spectrum disorder (NMOSD). However, it is not known which B cells are the major …
AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance
S Jarius, B Wildemann - Nature Reviews Neurology, 2010 - nature.com
Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …