The signalling pathways operational in quiescent, post-development vasculature remain
enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction
or deregulated blood vessel function contributes to multiple diseases, including diabetic …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

The Akt signaling pathway controls several cellular functions in the cardiovascular system;
however, its role in atherogenesis is unknown. Here, we show that the genetic ablation of …

Although numerous studies have implicated Akt and Src kinases in vascular endothelial
growth factor (VEGF) and Angiopoietin‐1 (Ang‐1)‐induced endothelial‐barrier regulation, a …

Abstract Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation
and stability. Here we identify the transcription factor ERG as a key regulator of endothelial …

Objective—Vascular smooth muscle cell (VSMC) apoptosis occurs at low levels in
atherosclerotic plaques and in vessel remodeling; however, the consequences and …

We investigated the functions of Akt during vascular development and remodeling by using
an inducible endothelial cell-specific driver of the dominant-active myrAkt. We found that …