Multidrug resistance (MDR) can be a serious complication for the treatment of cancer as well
as for microbial and parasitic infections. Dysregulated overexpression of several members of …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest
protein classes known, and counts numerous proteins involved in the trafficking of biological …

The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …

P-glycoprotein (P-gp or ABCB1) is a member of the broad family of ABC transporters. P-gp
participates in the establishment of physiological barriers limiting cellular access of a large …

Several members of different families of the ATP-binding cassette (ABC) superfamily of
transport proteins are capable of transporting an extraordinarily structurally diverse array of …

The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …

ABCG2 is best known as a multidrug transporter capable of conferring resistance to cancer
cells. However, the protein is also inherently expressed in numerous barrier tissues and …