The STK11/LKB1 gene encodes a ubiquitously expressed serine/threonine kinase that is
mutated in multiple sporadic cancers including non-small cell lung carcinomas, pancreatic …

Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers
Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of …

Elucidating the contribution of somatic mutations to cancer is essential for personalized
medicine. STK11 (LKB1) appears to be inactivated in human cancer. However, somatic …

LKB1/STK11 is a tumor suppressor and a negative regulator of mammalian target of
rapamycin signaling. It is inactivated in 30% of lung cancer cell lines but only 5–15% of …

The LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas
and cervical cancers and germline mutations are causative for Peutz-Jeghers syndrome …

The LKB1 serine/threonine kinase is a tumour suppressor responsible for the inherited
familial cancer disorder Peutz-Jeghers syndrome and is inactivated in a large percentage of …

To investigate whether genetic alteration of the STK11 (serine/threonine kinase 11)/LKB1
tumor-suppressor gene is involved in the carcinogenesis of head and neck squamous cell …

Somatic LKB1 serine/threonine kinase alterations are rare in sporadic cancers, with the
exception lung adenocarcinoma, but no mutations in squamous cell or large cell primary …

Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz–
Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in …

The tumor suppressor LKB1 is inactivated in 90% of Peutz–Jeghers cancer syndrome, 30-
40% of non-small cell lung carcinoma, and a variety of other cancers, indicating the loss of …