Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia
Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
BIN1 localizes the L-type calcium channel to cardiac T-tubules
The BAR domain protein superfamily is involved in membrane invagination and
endocytosis, but its role in organizing membrane proteins has not been explored. In …
endocytosis, but its role in organizing membrane proteins has not been explored. In …
BIN1 is reduced and Cav1. 2 trafficking is impaired in human failing cardiomyocytes
BACKGROUND: Heart failure is a growing epidemic, and a typical aspect of heart failure
pathophysiology is altered calcium transients. Normal cardiac calcium transients are …
pathophysiology is altered calcium transients. Normal cardiac calcium transients are …
Isoproterenol promotes rapid ryanodine receptor movement to bridging integrator 1 (bin1)–organized dyads
Y Fu, SA Shaw, R Naami, CL Vuong, WA Basheer… - Circulation, 2016 - Am Heart Assoc
Background—The key pathophysiology of human acquired heart failure is impaired calcium
transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at …
transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at …
BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are at the center of new
cell-based therapies for cardiac disease, but may also serve as a useful in vitro model for …
cell-based therapies for cardiac disease, but may also serve as a useful in vitro model for …
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
C Fugier, AF Klein, C Hammer, S Vassilopoulos… - Nature medicine, 2011 - nature.com
Myotonic dystrophy is the most common muscular dystrophy in adults and the first
recognized example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) …
recognized example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) …
Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)
JL Caldwell, CER Smith, RF Taylor, A Kitmitto… - Circulation …, 2014 - Am Heart Assoc
Rationale: Transverse tubules (t-tubules) regulate cardiac excitation–contraction coupling
and exhibit interchamber and interspecies differences in expression. In cardiac disease, t …
and exhibit interchamber and interspecies differences in expression. In cardiac disease, t …
Cardiac T-tubule microanatomy and function
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
Disrupted Membrane Structure and Intracellular Ca2+ Signaling in Adult Skeletal Muscle with Acute Knockdown of Bin1
A Tjondrokoesoemo, KH Park, C Ferrante… - PLoS …, 2011 - journals.plos.org
Efficient intracellular Ca2+ ([Ca2+] i) homeostasis in skeletal muscle requires intact triad
junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal …
junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal …
Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation
Abstract The mammalian Bin1/Amphiphysin II gene encodes an assortment of alternatively
spliced adapter proteins that exhibit markedly divergent expression and subcellular …
spliced adapter proteins that exhibit markedly divergent expression and subcellular …