Stem cell self-renewal is tightly controlled by the concerted action of stem cell-intrinsic
factors and signals within the niche. Niche signals often function within a short range …

Growing body of evidence confirms that cell–cell and cell–extracellular matrix adhesion
within stem cell niches is essential for the establishment and maintenance of niche …

Stem cells constitute a source of self-renewing cells with a potential to differentiate into
distinct tissues. In the embryo, these cells supply the multiple different cell lineages …

The expression of adhesion molecules by stem cells within their niches is well described,
but what is their function? A conventional view is that these adhesion molecules simply …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …

Stem cell niche is a specialized and dynamic microenvironment around the stem cells which
plays a critical role in maintaining the stemness properties of stem cells. Over the years …

The potential of stem cells in regenerative medicine relies upon removing them from their
natural habitat, propagating them in culture, and placing them into a foreign tissue …

The complexity of stem cell niches poses a tremendous challenge to understanding
mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche …

We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are
regulated by external signals and draw three main conclusions. First, the spatial definition of …

Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain
tissue homeostasis and repair throughout the lifetime of an organism. The development of …