Background NLRP3 inflammasome mediates IL-1β maturation, therefore plays a vital role in
the development of IBD. Curcumin is known for possessing strong anti-inflammatory …

Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease (IBD).
The conventional drugs for UC may induce severe side effects. Herbal medicine is …

Background and aims Although a series of studies have shown that curcumin can exert anti-
inflammatory effects in colitis by inhibiting NF-κB activation, whether these anti-inflammatory …

Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and
danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple …

NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease
including colitis due to its potential ability to induce IL-1β secretion. Emerging studies have …

A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel
disease (IBD). High-level fecal deoxycholic acid (DCA) caused by HFD contributes to the …

Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects
through inhibition of NFkB. Several pathways including toll-like receptors (TLR) induce NFkB …

Dendritic cells (DCs) play a pivotal role as initiators in the pathogenesis of inflammatory
bowel disease and are regulated by the JAK/STAT/SOCS signaling pathway. As a potent …

Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds
of immunological diseases including colitis. However, there are few drugs targeting …

Turmeric is traditionally used as a spice and coloring in foods. Curcumin is the primary
active ingredient in the turmeric, and compelling evidence has shown that it has the ability to …