High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …

Aims High-mobility group (HMG) proteins are oncogenic in different cancers, including
cervical cancer; silencing their individual expression using sh-RNAs, siRNAs, and miRNAs …

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide with
increasing incidence and mortality in developed countries. Oncogenes and microRNAs …

High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized
by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of …

Abstract HMGA2 (High Mobility Group AT-hook 2) has been reported to promote colorectal
cancer (CRC) development by regulating the transcription of target genes. It participates in …

Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …

MicroRNAs (miRNAs) are important molecular regulatorsof cellular signaling and behavior.
They alter gene expression by targeting messenger RNAs, including those encoding …

Purpose: The high mobility group A2 (HMGA2) nonhistone chromosomal protein can
modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during …

Introduction: Emerging evidence demonstrates that the high mobility group A1 (HMGA1)
chromatin remodeling protein is a key molecular switch required by cancer cells for tumor …

The high-mobility group A (HMGA) proteins are frequently overexpressed in human
malignancies and correlate with the presence of metastases and reduced patient survival …