Bleeding is the most serious complication of warfarin anticoagulation therapy and is known
to occur even at patients with therapeutic international normalized ratio (INR) range …

Background The optimal dose of anticoagulant warfarin varies among patients to achieve
the target international normalised ratio. Although genetic variations related to warfarin …

MicroRNAs are small single stranded molecules that play a crucial role in regulation of
physiological and pathological processes. Recent studies showed that VKORC1 gene …

A substantial body of research has confirmed that Vitamin K epoxide reductase complex
subunit 1 (VKORC1) plays a role in contributing to the high interpatient variability in the …

Aim: The role of mirSNPs in the 3′ UTR of VKORC1, CYP2C9 and CYP4F2 genes that
could influence warfarin dose variability via a discrete miRNA-mediated mechanism remains …

Purpose: GATA4 and GATA6 are known to have potential roles in vascular regulation by
affecting vascular smooth muscle cell differentiation and atrial natriuretic peptide levels. The …

The anticoagulant warfarin is commonly used to control and prevent thrombotic disorders,
such as venous thromboembolism (VTE), which disproportionately afflicts African …

Aim: We conducted a genome-wide association study using the Illumina Exome Array to
identify coding SNPs that may explain additional warfarin dose variability. Patients & …

This study aimed to investigate the effects of genetic variants and haplotypes in the renin–
angiotensin system (RAS) on the risk of warfarin-induced bleeding complications at …

Objectives As the most common sustained cardiac arrhythmia, atrial fibrillation (AF) is
regarded as a heritable disease partially. Most former researches were concentrated in …