Thirty-eight patients with advanced breast cancer, multiple myeloma, and malignant
lymphoma were treated with partially purified (about 0.1%) leukocyte interferon. Patients …

Sixteen patients with advanced cancer were treated with recombinant-DNA-produced pure
leukocyte A interferon (IFLrA) intramuscularly in doses ranging from 3 to 198 X 106 units …

Eleven patients with malignant tumors were given injections of potent interferon prepared
from human leukocyte cultures. The preparation was given intramuscularly (since an …

IN laboratory animals both endogenously induced and passively administered interferon
have inhibitory effects on a wide variety of tumors, including those caused by oncogenic …

Follow-up data for 11 patients with non-Hodgkin's lymphoma treated with partially purified
human leukocyte interferon is presented. The interferon preparation used was 0.1% pure …

A multi-institutional trials program was initiated to define the effects of interferons in
disseminated human breast carcinoma. Interferon alpha, prepared from buffy coats, was …

Interferons are proteins elaborated by infected cells that protect noninfected cells from viral
infection. These proteins produce a temporary" antiviral state" by altering nucleotide …

Fifty-two patients with advanced cancer received sequentially escalating doses of 3 to 50
million units of recombinant DNA-produced alpha interferon by daily intramuscular injection …

We report the results of a trial of recombinant leukocyte A interferon in previously treated
patients with non-Hodgkin's lymphoma who were no longer responsive to chemotherapy …

Nine patients with refractory chronic myelogenous leukemia and severe symptomatic
thrombocytosis (≥ 1 x 106 platelets/mm3) were given partially purified human leukocyte …