Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function. While genetic factors are important in the etiology of …

Psychiatric disorders are complex multifactorial disorders involving chronic alterations in
neural circuit structure and function. While genetic factors play a role in the etiology of …

Understanding the origins of normal and pathological behavior is one of the most exciting
opportunities in contemporary biomedical research. There is increasing evidence that, in …

Many neurological and most psychiatric disorders are not due to mutations in a single gene;
rather, they involve molecular disturbances entailing multiple genes and signals that control …

Psychiatric diseases place a tremendous burden on affected individuals, their caregivers,
and the health care system. Although evidence exists for a strong inherited component to …

This issue of Biological Psychiatry includes three reviews focused on the influence of so-
called epigenetic mechanisms—key cellular processes that integrate diverse environmental …

Epigenetics is a mechanism that regulates gene expression independently of the underlying
DNA sequence, relying instead on the chemical modification of DNA and histone proteins …

Epigenetic mechanisms govern the transcription of the genome. Research with model
systems reveals that environmental conditions can directly influence epigenetic mechanisms …

The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex
involving both heritable and nonheritable factors. The absence of consistently replicated …