Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

Epigenetic events, which are somatically inherited through cell division, are potential drivers
of acquired drug resistance in cancer. The high rate of epigenetic change in tumours …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Aberrant methylation of CpG islands located at or near gene promoters is associated with
inactivation of gene expression during tumour development. It is increasingly recognised …

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the
frequent emergence of drug resistance leads to disease progression or tumor recurrence …

Drug resistance is a serious impediment to the treatment of cancer. However, the
mechanisms involved remain poorly understood. While it is widely held that the …

Despite the great progress in our understanding of the molecular basis of human cancer, the
heterogeneity of individual tumors and the evolutionary pressures imposed by therapy have …

A major obstacle in precision cancer medicine is the inevitable resistance to targeted
therapies. Tremendous effort and progress has been made over the past few years to …