Preexposure prophylaxis for HIV prevention: where have we been and where are we going?

JM Baeten, JE Haberer, AY Liu… - JAIDS Journal of Acquired …, 2013 - journals.lww.com
Preexposure prophylaxis (PrEP), in which HIV-uninfected persons with ongoing HIV risk use
antiretroviral medications to reduce their risk of acquiring HIV infection, is an efficacious and …

Pre-exposure prophylaxis to prevent HIV infection: current status, future opportunities and challenges

DS Krakower, KH Mayer - Drugs, 2015 - Springer
As the global incidence of HIV exceeds 2 million new infections annually, effective
interventions to decrease HIV transmission are needed. Randomized, placebo-controlled …

Pre-exposure prophylaxis (PrEP) in an era of stalled HIV prevention: Can it change the game?

R Eakle, F Venter, H Rees - Retrovirology, 2018 - Springer
Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years
where clinical trials have now demonstrated the efficacy of oral PrEP, and the field is scaling …

Defining success with HIV pre-exposure prophylaxis: a prevention-effective adherence paradigm

JE Haberer, DR Bangsberg, JM Baeten, K Curran… - Aids, 2015 - journals.lww.com
To date, six clinical trials have explored the efficacy of pre-exposure prophylaxis (PrEP)
against HIV infection using oral tenofovir and/or emtricitabine/tenofovir [1–6]. Efficacy ranged …

Pre-exposure prophylaxis for HIV prevention: safety concerns

RA Tetteh, BA Yankey, ET Nartey, M Lartey… - Drug safety, 2017 - Springer
Available evidence supports the efficacy of pre-exposure prophylaxis (PrEP) in decreasing
the incidence of human immunodeficiency virus (HIV) infection among high-risk individuals …

The impact of preexposure prophylaxis among men who have sex with men: an individual-based model

P Kasaie, J Pennington, MS Shah… - JAIDS Journal of …, 2017 - journals.lww.com
Objectives: Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection
among individuals at high risk, including men who have sex with men (MSM). Although its …

Packaging PrEP to prevent HIV: an integrated framework to plan for pre-exposure prophylaxis implementation in clinical practice

K Underhill, D Operario, MR Skeer… - JAIDS Journal of …, 2010 - journals.lww.com
PrEP entails providing HIV-negative individuals with ARV drugs, and it is widely anticipated
as one of the most promising new prevention strategies. The PrEP drugs that have been …

Pre-exposure prophylaxis for sexually-acquired HIV risk management: a review

J Wilton, H Senn, M Sharma… - HIV/AIDS-Research and …, 2015 - Taylor & Francis
Despite significant efforts, the rate of new HIV infections worldwide remains unacceptably
high, highlighting the need for new HIV prevention strategies. HIV pre-exposure prophylaxis …

Preexposure prophylaxis for the prevention of HIV infection: evidence report and systematic review for the US Preventive Services Task Force

R Chou, C Evans, A Hoverman, C Sun, T Dana… - Jama, 2019 - jamanetwork.com
Importance Effective prevention strategies for HIV infection are an important public health
priority. Preexposure prophylaxis (PrEP) involves use of antiretroviral therapy (ART) daily or …

Effectiveness and safety of oral HIV preexposure prophylaxis for all populations

VA Fonner, SL Dalglish, CE Kennedy, R Baggaley… - Aids, 2016 - journals.lww.com
Objective: Preexposure prophylaxis (PrEP) offers a promising new approach to HIV
prevention. This systematic review and meta-analysis evaluated the evidence for use of oral …