For the nervous system to translate experience into memory and behavior, lasting structural
change at synapses must occur. This requirement is clearly evident during critical periods of …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

Class I major histocompatibility complex (class I MHC) molecules, known to be important for
immune responses to antigen, are expressed also by neurons that undergo activity …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

Immune molecules have been discovered recently to play critical roles in the development,
function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed …

Recently, MHC class I molecules have been shown to be important for the retraction of
synaptic connections that normally occurs during development [Huh, GS, Boulanger, LM …

Until recently, neurons in the healthy brain were considered immune-privileged because
they did not appear to express MHC class I (MHCI). However, MHCI mRNA was found to be …

To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …

Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of
the CNS have been studied in vitro. Astrocytes in primary cultures, but neither …

Major histocompatibility complex class I (MHCI) genes were discovered unexpectedly in
healthy CNS neurons in a screen for genes regulated by neural activity. In mice lacking just …