Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

For the past several decades, research in understanding the molecular basis of human
aging has progressed significantly with the analysis of premature aging syndromes …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the
best characterized human progeroid syndromes. HGPS is caused by a point mutation in …

The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …

The molecular mechanisms involved in human aging are complicated. Two progeria
syndromes, Werner's syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS) …

In the past several years, remarkable progress has been made in the understanding of the
mechanisms of premature aging. These rare, genetic conditions offer valuable insights into …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal genetic disorder that is
characterized by segmental accelerated aging. The major causal mutation associated with …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Hutchinson–Gilford progeria syndrome (HGPS), a fatal premature aging disease, is caused
by a single‐nucleotide mutation in the LMNA gene. Previous reports have focused on …