Lung cancer is the leading cause of cancer deaths throughout the world. The majority of
patients are diagnosed with locally advanced or metastatic disease when surgery, the best …

An in-depth understanding of lung cancer biology and mechanisms of tumor progression
has facilitated significant advances in the treatment of lung cancer. There remains a …

Introduction The interaction of immune cells and cancer cells shapes the
immunosuppressive tumor microenvironment. For successful cancer immunotherapy …

Immunotherapy of non-small cell lung cancer (NSCLC), by immune checkpoint inhibitors,
has profoundly improved the clinical management of advanced disease. However, only a …

Although the incidence of lung cancer is declining, the prognosis remains poor. This is likely
due to lack of early detection and only recent developments in selective cancer therapies …

The therapeutic algorithm of lung cancer has recently been revolutionized by the emergence
of immune checkpoint inhibitors. However, an objective and durable response rate remains …

Simple Summary The lung cancer treatment paradigm has been completely changed by
immunotherapy; however, less than half of the treated patients obtain a response, and an …

Lung cancer is the number one cause of cancer-related deaths. The malignancy is
characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage …

Recent breakthroughs in targeted therapy and immunotherapy have revolutionized the
treatment of lung cancer, the leading cause of cancer-related deaths in the United States …

Tumor-associated immune responses have polarized effects in regulating tumor growth.
Although a clear association has been shown between the tumor immune response and …