p16 INK4a and β-catenin alterations in rat liver tumors induced by NNK
LC Pulling, DM Klinge, SA Belinsky - Carcinogenesis, 2001 - academic.oup.com
Inactivation of the p16 INK4a (p16) tumor suppressor gene by promoter hypermethylation
and mutation within exon 3 of β-catenin represent two of the more common gene alterations …
and mutation within exon 3 of β-catenin represent two of the more common gene alterations …
High frequency of p16INK4A gene alterations in hepatocellular carcinoma
The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …
Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver
A Tannapfel, M Benicke, A Katalinic, D Uhlmann… - Gut, 2000 - gut.bmj.com
BACKGROUND Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and
K-ras mutations are among the most frequent genetic alterations in human malignancies …
K-ras mutations are among the most frequent genetic alterations in human malignancies …
Frequent Aberrant Methylation of p16INK4a in Primary Rat Lung Tumors
DS Swafford, SK Middleton, WA Palmisano… - … and cellular biology, 1997 - Taylor & Francis
The p16 INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous
deletion or methylation of the 5′ CpG island in cell lines derived from human non-small-cell …
deletion or methylation of the 5′ CpG island in cell lines derived from human non-small-cell …
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
IP Pogribny, SJ James - Cancer letters, 2002 - Elsevier
Previous studies have established that chronic dietary insufficiency of the lipotropic nutrients
choline and methionine with or without chemical initiation is hepatocarcinogenic in the rat …
choline and methionine with or without chemical initiation is hepatocarcinogenic in the rat …
Hypermethylation of the p16 Ink4a promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines
AC Patel, CH Anna, JF Foley, PS Stockton… - …, 2000 - academic.oup.com
Primary lung tumors from B6C3F1 mice and mouse lung cell lines were examined to
investigate the role of transcriptional silencing of the p16 Ink4a tumor suppressor gene by …
investigate the role of transcriptional silencing of the p16 Ink4a tumor suppressor gene by …
p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus
YS Bian, MC Osterheld, C Fontolliet, FT Bosman… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: The potential role of p16 inactivation by CDKN2A/p16 promoter
hypermethylation and/or loss of heterozygosity (LOH) of the CDKN2A gene was investigated …
hypermethylation and/or loss of heterozygosity (LOH) of the CDKN2A gene was investigated …
Cloning of the hamster p16 gene 5′ upstream region and its aberrant methylation patterns in pancreatic cancer
M Hanaoka, K Shimizu, M Shigemura, A Kato… - Biochemical and …, 2005 - Elsevier
The hamster model of pancreatic carcinogenesis is useful for understanding the
development of human pancreatic cancer. However, there is only a small amount of hamster …
development of human pancreatic cancer. However, there is only a small amount of hamster …
p16INK4A–alterations in primary angiosarcoma of the liver
A Tannapfel, M Weihrauch, M Benicke, D Uhlmann… - Journal of …, 2001 - Elsevier
Background/Aims: Alterations in the p16 (CDKN2/MTS-1/INK4A) gene have been implicated
in the tumorigenesis of different human cancers. Recent evidence shows that transcriptional …
in the tumorigenesis of different human cancers. Recent evidence shows that transcriptional …
Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
SA Belinsky, KJ Nikula… - Proceedings of the …, 1998 - National Acad Sciences
The p16 INK4a (p16) tumor suppressor gene can be inactivated by promoter region
hypermethylation in many tumor types including lung cancer, the leading cause of cancer …
hypermethylation in many tumor types including lung cancer, the leading cause of cancer …