Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

X Hua, G Liang, J Chao, D Wang - Journal of Hazardous Materials, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is an
emerging pollutant transformed from 6-PPD. However, the effect of 6-PPDQ exposure on …

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

X Hua, D Wang - Environmental Science & Technology, 2023 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common
additives used in rubber, enters the environment due to significant emissions of tire wear …

Exposure to 6-PPD quinone at environmentally relevant concentrations causes abnormal locomotion behaviors and neurodegeneration in Caenorhabditis elegans

X Hua, X Feng, G Liang, J Chao… - Environmental Science & …, 2023 - ACS Publications
6-PPD quinone (6-PPDQ) can be transformed from 6-PPD through ozonation. Nevertheless,
the potential neurotoxicity of 6-PPDQ after long-term exposure and the underlying …

Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and …

H Liu, X Tan, Y Wu, X Li, Z Hu, S Lei, W Fan… - Science of The Total …, 2024 - Elsevier
PPD quinone (6-PPDQ), an emerging environmental pollutant, is converted based on 6-PPD
via ozonation. However, a systematic evaluation on possible neurotoxicity of long-term and …

Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans

X Hua, D Wang - Science of The Total Environment, 2024 - Elsevier
The exposure risk of 6-PPD quinone (6-PPDQ) has aroused increasing concern. In the
natural environment, 6-PPDQ could interact with other pollutants, posing more severe …

Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

X Wan, G Liang, D Wang - Chemosphere, 2024 - Elsevier
CPPD quinone (CPPDQ) is a member of PPDQs, which was widely distributed in different
environments. Using Caenorhabditis elegans as an animal model, we here examined …

Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans

X Hua, D Wang - Environmental Pollution, 2023 - Elsevier
Caenorhabditis elegans is a useful model for examining metabolic processes and related
mechanisms. We here examined the effect of exposure to N-(1, 3-dimethylbutyl)-N′-phenyl …

Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell …

X Hua, X Feng, G Liang, J Chao, D Wang - Journal of Hazardous Materials, 2023 - Elsevier
Abstract Recently, 6-PPD quinone (6-PPDQ), a derivative of tire antioxidant 6-PPD, was
reported to have acute toxicity for organisms. However, the possible reproductive toxicity of 6 …

Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans

X Hua, X Feng, G Liang, J Chao, D Wang - Science of The Total …, 2023 - Elsevier
Abstract 2-((4-Methylpentan-2-yl) amino)-5-(phenylamino) cyclohexa-2, 5-diene-1, 4-dione
(6-PPDQ) is the ozonation product of 6-PPD, a commonly used tire preservative. Although …

Chronic di (2-ethylhexyl) phthalate exposure leads to dopaminergic neuron degeneration through mitochondrial dysfunction in C. elegans

ML Huang, PL Yen, CH Chang, VHC Liao - Environmental Pollution, 2022 - Elsevier
Abstract The plasticizer di (2-ethylhexyl) phthalate (DEHP) is frequently detected in the
environment due to the abundance of its use. These levels might be hazardous to human …