Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
Genome-wide association studies (GWAS) have identified over 100 risk loci for
schizophrenia, but the causal mechanisms remain largely unknown. We performed a …
schizophrenia, but the causal mechanisms remain largely unknown. We performed a …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
Genome-wide association studies of schizophrenia: does bigger lead to better results?
SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …
mechanisms leading to manifestation of the disease. New and more effective treatments for …
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …
genetic associations with such disorders, but better methods are needed to derive the …
[HTML][HTML] Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
[HTML][HTML] Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
[HTML][HTML] Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
[HTML][HTML] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …