[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Age‐related macular degeneration—clinical review and genetics update

R Ratnapriya, EY Chew - Clinical genetics, 2013 - Wiley Online Library
Age‐related macular degeneration (AMD) is the leading cause of central vision impairment
in persons over the age of 50 years in developed countries. Both genetic and non‐genetic …

The molecular genetic basis of age-related macular degeneration: an overview

S Katta, I Kaur, S Chakrabarti - Journal of genetics, 2009 - Springer
Age-related macular degeneration (AMD) is a complex disorder of the eye and the third
leading cause of blindness worldwide. With a multifactorial etiology, AMD results in …

Genetics of age-related macular degeneration: current concepts, future directions

MM DeAngelis, AC Silveira, EA Carr… - Seminars in …, 2011 - Taylor & Francis
Age-related macular degeneration (AMD) is a progressive degenerative disease which
leads to blindness, affecting the quality of life of millions of Americans. More than 1.75 …

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics

MB Gorin - Molecular aspects of medicine, 2012 - Elsevier
Age-related macular degeneration (AMD) is a common condition among the elderly
population that leads to the progressive central vision loss and serious compromise of …

Early and intermediate age-related macular degeneration: update and clinical review

A García-Layana, F Cabrera-López… - … interventions in aging, 2017 - Taylor & Francis
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision
loss in developed countries. With the aging of population, AMD will become globally an …

Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration

A Swaroop, EY Chew, C Bowes Rickman… - Annual review of …, 2009 - annualreviews.org
Aging-associated neurodegenerative diseases significantly influence the quality of life of
affected individuals. Genetic approaches, combined with genomic technology, have …

Mechanisms of age‐related macular degeneration and therapeutic opportunities

M van Lookeren Campagne, J LeCouter… - The Journal of …, 2014 - Wiley Online Library
As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …

Genetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease management

RR Priya, EY Chew, A Swaroop - Ophthalmology, 2012 - Elsevier
BACKGROUND: Age-related macular degeneration (AMD) is a common cause of visual
impairment in individuals> 55 years of age worldwide. The varying clinical phenotypes of …

Genetics of age-related macular degeneration (AMD)

MM DeAngelis, LA Owen, MA Morrison… - Human molecular …, 2017 - academic.oup.com
Age-related macular degeneration (AMD) is a progressive blinding disease and represents
the leading cause of visual impairment in the aging population. AMD affects central vision …