Page 1 Pharmacology Research And Textbook 2 Chapter1: HIV-1 Integrase Inhibitors and
Neurodevelopment Chapter2: Coenzyme Q10 Chapter3: Ferroptosis Author in Chief …

Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome,
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …

AIDS is currently treated with a combination therapy of reverse transcriptase and protease
inhibitors. Recently, the FDA approved a drug targeting HIV-1 entry into cells. There are …

Importance of the field: Integrase inhibitors are the newest class of antiretroviral agents
developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) …

From the discovery of HIV-1 integrase (IN) inhibitors using enzyme-based assays in 1992, it
has taken 15 years to achieve success in human clinical trials. Currently available …

The long process of HIV-1 integrase inhibitor discovery and development can be attributed
to both the complexity of HIV-1 integration and poor 'integration'of these researches into …

Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the
obligatory integration of the viral DNA into the infected cell chromosome. As no cellular …

Human immunodeficiency virus (HIV) infection has been transformed over the past two
decades from a fatal to a chronic disease, because of combination antiretroviral therapy—a …

AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people
are HIV-infected and new cases are being diagnosed every year. Despite the fact that …

HIV-1 integrase is one of the three enzymes, which are critical for viral replication. It
catalyzes the integration of the HIV genome into the cellular chromosome. Since there is no …